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The effect of in vitro enzymatic degradation on 3D printed poly (ε-caprolactone) scaffolds: focus on morphological, chemical and mechanical properties

机译：体外酶促降解对3D打印聚（ε-己内酯）支架的影响：注重形态，化学和机械性能

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In recent years, Tissue Engineering (TE) field has been significantly benefited from advanced techniques, such as Additive Manufacturing (AM), for the design of customized 3D scaffolds with the aim of guided tissue repair. Among the wide range of materials available to biomanufacture 3D scaffolds, Poly(ε-caprolactone) (PCL) clearly arises as the synthetic polymer with the highest potential due to its unique properties, namely biocompatibility, biodegradability, thermal/chemical stability and processability. This paper reports for the first time the effect of pore geometry on the in vitro enzymatic chain cleavage mechanism of PCL scaffolds manufactured by AM extrusion process. Morphological analysis performed by SEM and μ-CT suggested a uniform reduction of filament diameter, while increasing the scaffolds porosity. Thermal analysis (DSC) showed an increment in the crystallinity degree while the molecular weight, evaluated through SEC, remains almost constant during the incubation period (25 days). Mechanical analysis performed under static compression highlighted a decrease in the compressive modulus and maximum stress over time, probably related with the significant weight loss of the scaffolds. All these results suggest that PCL scaffolds undergo enzymatic degradation through a surface erosion mechanism, with significant variations of the mechanical, physical and chemical properties, but with little influence on pore geometry. Keywords: Tissue Engineering, Biomanufacturing, Polycaprolactone, Scaffolds, Enzymatic degradation
机译：近年来，组织工程（TE）领域已从诸如增材制造（AM）之类的先进技术中受益匪浅，用于设计定制3D支架，以指导组织修复。在可用于生物制造3D支架的多种材料中，聚（ε-己内酯）（PCL）显然是具有最高潜力的合成聚合物，这归因于其独特的特性，即生物相容性，生物降解性，热/化学稳定性和可加工性。本文首次报道了孔的几何形状对通过AM挤出工艺制备的PCL支架的体外酶链裂解机理的影响。通过SEM和μ-CT进行的形态分析表明，细丝直径均匀减小，同时增加了支架的孔隙率。热分析（DSC）显示结晶度增加，而通过SEC评估的分子量在孵育期间（25天）几乎保持恒定。在静态压缩下进行的机械分析表明，压缩模量和最大应力会随着时间的推移而降低，这可能与支架的显着重量减少有关。所有这些结果表明，PCL支架通过表面侵蚀机制进行酶降解，机械，物理和化学性质发生显着变化，但对孔的几何形状影响很小。关键词：组织工程，生物制造，聚己内酯，支架，酶促降解

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